Theory August 2011

4 September 2011, 00:07

Dr. Tushar Maniar


August 2011

100 Marks

3 Hours


1. Draw pedigree notations. Draw 4 generation of inheritance in a case of X linked Dominant disease. Enumerate the conditions with this inheritance. (4+4+2)

2. Describe the diagnostic approach and management in a case of frequently relapsing and steroid dependent Nephrotic syndrome. (5+5)

3. Write a short note on (a) ROC curve (b) forest plot. (5+5)

4. Describe various mechanisms of drug resistance, with examples. Mention in brief strategies to prevent resistance. (7+3)

5. Describe the pathogentic mechanism of injury in Submersion /drowning. Discuss initial steps of resuscitation and subsequent hospital management. ( 3+4+3)

6. Provide a diagrammatic representation of urea cycle. Indicate and name related disorders of urea cycle metabolism at each step. Name the drugs used in management of Urea cycle disorder (4+4+2)

7. Describe the pathophysiology of Hypernatremia. Briefly discuss the management of a child with serum Sodium of 160 meq/lit presenting with moderate dehydration. (5+5)

8. Write indications and complications: (a)Liver transplantation (b) Hematopoietic Stem cell Transplant.(5+5)

9. Define Dengue haemorrhagic fever and Dengue shock Syndrome. Describe treatment of Dengue shock syndrome. (2+2+6)

10. Define SIRS (systemic inflammatory response syndrome). Describe mechanisms of Vasodilatory Shock. Write steps in management of Septic shock. (2+3+5)

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